Syed Qadri
MD, PhD

Research and expertise

• Background and interests

   

  The overarching objective of Dr. Qadri’s research is to understand the molecular mechanisms regulating RBC product quality during blood bank storage; and RBC function in systemic diseases. More specifically, the research in his lab aims at defining the influence of exogenous and endogenous factors that impact RBC lifespan by using various cellular and molecular biology approaches as well as in vivo studies.

  Research areas of specialty:

  • red blood cell (RBC) pathophysiology in humans and animal models
  • RBC and plasma transfusion
  • blood product characteristics
• Education
  • Post Doctorate Fellow (PDF), Canadian Blood Services and Department of Pathology and Molecular Medicine, McMaster University, Canada, 2015 to 2017
  • PDF, Department of Pharmacology, University of Saskatchewan, Canada, 2012 to 2014
  • Doctoral degree, Eberhard Karls Universität Tübingen, Germany, 2011
  • Medical degree, Universitatea din Oradea, Romania, 2006
• Course taught
  • HLSC2110/MLSC1110
  • HLSC2460
  • HLSC2461
  • MLSC4400/4401
• Publications

  For a comprehensive list of publications, please visit PubMed.

  Bissinger R, Qadri SM, Artunc F. Eryptosis: a driver of anemia in chronic kidney disease. Curr Opin Nephrol Hypertens. 2024, 33(2):220-225.
  

   

  Kennedy B, Mirza S, Mandiangu T, Bissinger R, Stotesbury TE, Jones-Taggart H, Green-Johnson J, Qadri SM. Examination of Bovine Red Blood Cell Death in Vitro in Response to Pathophysiologic Proapoptotic Stimuli. Front Biosci (Landmark Ed). 2023, 6;28(12):331.
  

   

  Williams A, Bissinger R, Shamaa H, Patel S, Bourne L, Artunc F, Qadri SM. Pathophysiology of red blood cell dysfunction in diabetes and its complications. Pathophysiology 2023, 30(3), 327-345.
  

   

  Qadri SM, Liu Y, Barty RL, Heddle NM, Sheffield WP. A positive blood culture is associated with a lower haemoglobin increment in hospitalized patients after red blood cell transfusion. Vox Sanguinis 2023; 118(1):33-40.
  

   

  Himbert S, D’Alessandro A, Qadri SM, Majcher MJ, Hoare T, Sheffield WP, Nagao M, Nagle JF, Rheinstädter MC. The bending rigidity of the red blood cell cytoplasmic membrane. PLoS One 2022; 17(8):e0269619.
  

   

  Stephenson D, Nemkov T, Qadri SM, Sheffield WP, D'Alessandro A. Inductively-coupled plasma mass spectrometry – Novel insights from an old technology into stressed red blood cell physiology. Frontiers in Physiology 2022; 13:828087
  

   

  Himbert S, Qadri SM, Sheffield WP, Schubert P, D’Alessandro A, Rheinstädter MC. Blood bank storage of red blood cells alters RBC cytoplasmic membrane order and bending rigidity. PLoS One 2021; 16(11):e0259267
  

   

  Bissinger R, Nemkov T, D´Alessandro A, Grau M, Dietz T, Bohnert BN, Essigke D, Wörn M, Schaefer L, Xiao M, Beirne JM, Kalo MZ, Schork A, Bakchoul T, Omage K, Kong L, Gonzalez-Menendez I, Quintanilla-Martinez L, Fehrenbacher B, Schaller M, Dhariwal A, Birkenfeld AL, Grahammer F, Qadri SM, Artunc F. Proteinuric chronic kidney disease is associated with altered red blood cell lifespan, rheology and cellular metabolism. Kidney International 2021; 100(6):1227-1239
  

   

  Nemkov T, Qadri SM, Sheffield WP, D’Alessandro A. Decoding the metabolic landscape of pathophysiologic stress-induced cell death in anucleate red blood cells. Blood Transfusion 2020; 18(2):130-142
  

   

  Bissinger R, Petkova-Kirova P, Mykhailova O, Oldenborg PA, Novikova E, Donkor DA, Dietz T, Bhuyan AAM, Sheffield WP, Grau M, Artunc F, Kaestner L, Acker JP, Qadri SM. Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells. Cell Communication and Signaling 2020; 18(1):155
  

   

  Bider RC, Lluka T, Himbert S, Khondker A, Qadri SM, Sheffield WP, Rheinstädter MC. Stabilization of lipid membranes through partitioning of the blood bag plasticizer Di-2-ethylhexyl phthalate (DEHP). Langmuir 2020; 36(40):11899-11907
  

   

  Eltringham-Smith LJ, Yu R, Qadri SM, Wang Y, Bhakta V, Pryzdial EL, Crosby JR, Ni H, Sheffield WP. Prothrombin, alone or in complex concentrates or plasma, reduces bleeding in a mouse model of blood exchange-induced coagulopathy. Scientific Reports 2019; 9(1):13029
  

   

  Qadri SM, Eltringham-Smith LJ, Bhakta V, Sheffield WP. Thromboelastometry reveals similar hemostatic properties of purified fibrinogen and a mixture of purified cryoprecipitate protein components. Clinical Chemistry and Laboratory Medicine 2018; 26;56(8):e210-e213
  

   

  Qadri SM, Donkor DA, Yan M, Ning S, Branch DR, Seghatchian J, Sheffield WP. Red blood cells, still vital after all these years: Commentary on Canadian Blood Services’ International Symposium 2017. Transfusion and Apheresis Science 2018; 57(2):298-303
  

   

  Qadri SM, Donkor DA, Nazy I, Branch DR, Sheffield WP. Bacterial neuraminidase-mediated erythrocyte desialylation provokes cell surface aminophospholipid exposure. European Journal of Haematology 2018; 100(5):502-510
  

   

  Kempe-Teufel DS, Bissinger R, Qadri SM, Wagner R, Peter A, Lang F. Cellular markers of eryptosis are altered in type 2 diabetes. Clinical Chemistry and Laboratory Medicine 2018; 56:e177-180
  

   

  Qadri SM, Chen D, Schubert P, Perruzza DL, Bhakta V, Devine DV, Sheffield WP. Pathogen inactivation by riboflavin and ultraviolet light illumination accelerates the red blood cell storage lesion and promotes eryptosis. Transfusion 2017; 57(3):661-673
  

   

  Qadri SM, Bissinger R, Solh Z, Oldenborg PA. Eryptosis in health and disease: A paradigm shift towards understanding the (patho)physiological implications of programmed cell death of erythrocytes. Blood Reviews 2017; 31(6):349-361
  

   

  Qadri SM, Chen D, Schubert P, Devine DV, Sheffield WP. Early γ-irradiation and subsequent storage of red cells in SAG-M additive solution potentiates energy imbalance, microvesiculation and susceptibility to stress-induced apoptotic cell death. Vox Sanguinis 2017; 112(5):480-483
• Research collaborators
  • Centre for Innovation, Canadian Blood Services
• Grants

  Research funded by the Natural Sciences and Engineering Research Council of Canada, Canadian Blood Services, and Canadian Hematology Society