Skip to main content
Ontario Tech acknowledges the lands and people of the Mississaugas of Scugog Island First Nation.

We are thankful to be welcome on these lands in friendship. The lands we are situated on are covered by the Williams Treaties and are the traditional territory of the Mississaugas, a branch of the greater Anishinaabeg Nation, including Algonquin, Ojibway, Odawa and Pottawatomi. These lands remain home to many Indigenous nations and peoples.

We acknowledge this land out of respect for the Indigenous nations who have cared for Turtle Island, also called North America, from before the arrival of settler peoples until this day. Most importantly, we acknowledge that the history of these lands has been tainted by poor treatment and a lack of friendship with the First Nations who call them home.

This history is something we are all affected by because we are all treaty people in Canada. We all have a shared history to reflect on, and each of us is affected by this history in different ways. Our past defines our present, but if we move forward as friends and allies, then it does not have to define our future.

Learn more about Indigenous Education and Cultural Services

Syed Qadri
MD, PhD

Assistant Professor

Faculty of Health Sciences

Assistant Professor (part-time), Department of Pathology and Molecular Medicine, McMaster University (status-only)

Contact information

Shawenjigewining Hall - Room 451
North Oshawa
2000 Simcoe Street North
Oshawa, ON L1G 0C5

905.721.8668

syedm.qadri@ontariotechu.ca

Research topics

  • transfusion science
  • blood products
  • red blood cells
  • pathogen inactivation treatment
  • erythropoiesis
  • anemia
  • cellular signaling

Research and expertise

  • Background and interests

    Research areas of specialty:

    • red blood cell (RBC) pathophysiology in humans and animal models
    • RBC and plasma transfusion
    • blood product characteristics

    Research background and interests:

    The overarching objective of Dr. Qadri’s research is to understand the molecular mechanisms regulating RBC product quality during blood bank storage; and RBC function in systemic diseases. More specifically, the research in his lab aims at defining the influence of exogenous and endogenous factors that impact RBC lifespan by using various cellular and molecular biology approaches as well as in vivo studies.

  • Publications

    For a comprehensive list of publications, please visit PubMed.

    • Bissinger R, Nemkov T, D'Alessandro A, Grau M, Dietz T, Bohnert BN, Essigke D, Wörn M, Schaefer L, Xiao M, Beirne JM, Kalo MZ, Schork A, Bakchoul T, Omage K, Kong L, Gonzalez-Menendez I, Quintanilla-Martinez L, Fehrenbacher B, Schaller M, Dhariwal A, Birkenfeld AL, Grahammer F, Qadri SM, Artunc F. Proteinuric chronic kidney disease is associated with altered red blood cell lifespan, deformability and metabolism. Kidney Int. 2021; S0085-2538(21)00858-9.
    • Himbert S, Qadri SM, Sheffield WP, Schubert P, D’Alessandro A, Rheinstädter MC. Blood bank storage of red blood cells alters RBC cytoplasmic membrane order and bending rigidity. PloS One. 2021
    • Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells. Bissinger R, Petkova-Kirova P, Mykhailova O, Oldenborg PA, Novikova E, Donkor DA, Dietz T, Bhuyan AAM, Sheffield WP, Grau M, Artunc F, Kaestner L, Acker JP, Qadri SM. Cell Commun Signal. 2020; 18(1):155.
    • Bider RC, Lluka T, Himbert S, Khondker A, Qadri SM, Sheffield WP, Rheinstädter MC. Langmuir. Stabilization of Lipid Membranes through Partitioning of the Blood Bag Plasticizer Di-2-ethylhexyl phthalate (DEHP). 2020; 36(40):11899-11907.
    • Decoding the metabolic landscape of pathophysiological stress-induced cell death in anucleate red blood cells. Nemkov T, Qadri SM, Sheffield WP, D'Alessandro A. Blood Transfus. 2020; 18(2):130-142.
    • Eltringham-Smith LJ, Yu R, Qadri SM, Wang Y, Bhakta V, Pryzdial EL, Crosby JR, Ni H, Sheffield WP. Prothrombin, alone or in complex concentrates or plasma, reduces bleeding in a mouse model of blood exchange-induced coagulopathy. Sci Rep. 2019; 9(1):13029.
    • Qadri SM, Eltringham-Smith LJ, Bhakta V, Sheffield WP. Thromboelastometry reveals similar hemostatic properties of purified fibrinogen and a mixture of purified cryoprecipitate protein components. Clin Chem Lab Med. 2018; 56(8):e210-e213.
    • Qadri SM, Donkor DA, Yan M, Ning S, Branch DR, Seghatchian J, Sheffield WP. Red blood cells, still vital after all these years: Commentary on Canadian Blood Services' International Symposium 2017. Transfus Apher Sci. 2018; 57(2):298-303.
    • Qadri SM, Donkor DA, Nazy I, Branch DR, Sheffield WP. Bacterial neuraminidase-mediated erythrocyte desialylation provokes cell surface aminophospholipid exposure. Eur J Haematol. 2018; 100(5):502-510.
    • Kempe-Teufel DS, Bissinger R, Qadri SM, Wagner R, Peter A, Lang F. Cellular markers of eryptosis are altered in type 2 diabetes. Clin Chem Lab Med. 2018; 56(7):e177-e180.
    • Qadri SM, Bissinger R, Solh Z, Oldenborg PA. Eryptosis in health and disease: A paradigm shift towards understanding the (patho)physiological implications of programmed cell death of erythrocytes. Blood Rev. 2017; 31(6):349-361.
    • Qadri SM, Chen D, Schubert P, Devine DV, Sheffield WP. Early γ-irradiation and subsequent storage of red cells in SAG-M additive solution potentiate energy imbalance, microvesiculation and susceptibility to stress-induced apoptotic cell death. Vox Sang. 2017; 112(5):480-483.
    • Qadri SM, Chen D, Schubert P, Perruzza DL, Bhakta V, Devine DV, Sheffield WP. Pathogen inactivation by riboflavin and ultraviolet light illumination accelerates the red blood cell storage lesion and promotes eryptosis. Transfusion. 2017; 57(3):661-673.
    • Bissinger R, Lang E, Ghashghaeinia M, Singh Y, Zelenak C, Fehrenbacher B, Honisch S, Chen H, Fakhri H, Umbach AT, Liu G, Rexhepaj R, Liu G, Schaller M, Mack AF, Lupescu A, Birnbaumer L, Lang F, Qadri SM. Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2. Sci Rep. 2016; 6:30925
    • Qadri SM, Donkor DA, Bhakta V, Eltringham-Smith LJ, Dwivedi DJ, Moore JC, Pepler L, Ivetic N, Nazi I, Fox-Robichaud AE, Liaw PC, Sheffield WP. Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin. J Cell Mol Med. 2016; 20(4):710-20
    • Lang E, Bissinger R, Fajol A, Salker MS, Singh Y, Zelenak C, Ghashghaeinia M, Gu S, Jilani K, Lupescu A, Reyskens KM, Ackermann TF, Föller M, Schleicher E, Sheffield WP, Arthur JS, Lang F, Qadri SM. Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2. Sci Rep.; 5:17316.
  • Research collaborators
    • Centre for Innovation, Canadian Blood Services
  • Grants

    Canadian Blood Services Blood Efficiency Accelerator Award Program 

    • Project: Optimizing rejuvenation to improve the product quality of pathogen-inactivated and γ-irradiated red cell concentrates.  PI: W.P. Sheffield (McMaster), Co-I: S.M. Qadri, P. Schubert (UBC), D. V. Devine (UBC). $30,000 (2019) 
  • Course taught
    • Pathophysiology
  • Education
    • Post Doctorate Fellow (PDF), Canadian Blood Services and Department of Pathology and Molecular Medicine, McMaster University, Canada, 2015 to 2017
    • PDF, Department of Pharmacology, University of Saskatchewan, Canada, 2012 to 2014
    • Doctoral degree, Eberhard Karls Universität Tübingen, Germany, 2011
    • Medical degree, Universitatea din Oradea, Romania, 2006